Burnout · high-functioning exhaustion

For people who keep functioning while feeling exhausted inside.

When rest no longer restores anything, and everything still depends on you.

If prolonged stress or exhaustion continues to affect your daily life despite rest, time off or previous support, you are not alone. ONCE offers a carefully structured psilocybin-assisted pathway with professional screening, clinical support and integration.

Start a confidential preliminary assessment

Professional screening
Supervised access in Amsterdam
No promises, no hype

The ONCE pathway is not a replacement for medical or mental-health care.

A woman sitting at a desk in the evening, head in her hands, a notebook and laptop in front of her

You might be in the right place if:

You keep functioningWork gets done and responsibilities are met, but it takes more effort than it used to.

Rest does not restore youWeekends, time off or holidays bring only partial or short-lived relief.

You feel depleted insideMotivation, concentration, patience or emotional connection feel thinner than before.

You want a careful next stepA structured pathway with professional screening, support and integration.

About the ONCE pathway

ONCE is a professionally supported pathway that combines psilocybin-assisted sessions with psychological preparation and integration.

It is not a treatment for burnout. What feels like burnout can overlap with depression, anxiety, sleep disruption, physical health, medication effects or prolonged stress — which is why screening comes first.

Everyone begins with a confidential preliminary assessment to help understand your situation and whether this pathway may be appropriate for you.

Your current situationWe look at workload, recovery, health, support, and the pattern of stress over time.
Professional reviewQualified clinicians review your summary to consider suitability and risk. You may be invited for a screening conversation.
Preparation & in-person daysIf the pathway is appropriate, you continue with preparation, your in-person session in Amsterdam, and integration support afterwards.
Integration & return to daily lifeThe focus is on how any insight relates to work, relationships, boundaries and an ordinary week.

Learn how the pathway works

What research suggests

Controlled academic studies have looked at people whose difficulties overlap with depression or prolonged exhaustion. Research on burnout as a standalone indication is more limited.

Results vary between individuals and study populations. It is not possible to predict how any one person will respond.

See evidence and sources

30+controlled academic studies of psilocybin-assisted approaches in adults, across multiple clinical programmes.Figure pending source verification

Limitedresearch focused specifically on burnout as a standalone indication. Suitability is considered individually.Figure pending source verification

Research is evolving. ONCE does not promise specific outcomes.

Wondering whether exhaustion is all this is?

Start a confidential preliminary assessment

Takes about 4 minutes. You read your full summary before any contact details are requested.