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For loved ones

For loved ones

If you are exploring ONCE for someone close to you.

Supporting someone you care about can be difficult and uncertain. ONCE offers a carefully structured psilocybin-assisted pathway with professional screening, clinical support and integration.

Start a confidential preliminary assessment
  • Professional screening
  • Supervised access in Amsterdam
  • No promises, no hype

The ONCE pathway is not a replacement for medical or mental-health care.

Two women sitting on a sofa in conversation, one listening attentively

You might be in the right place if:

You are worried about someone you loveYou see they are struggling and want to help.
They have tried many thingsTherapy, medication or other approaches did not bring enough relief.
You want to understand what is involvedYou are looking for clear information, screening and professional care.
You want to support their next stepYou want to explore a structured, professionally supported pathway together.

About the ONCE pathway

ONCE is a professionally supported pathway that combines psilocybin-assisted sessions with psychological preparation and integration.

It is not a treatment and makes no promise of a particular result. The pathway is built around carefully structured access, professional support and evidence-informed practices.

Everyone begins with a confidential preliminary assessment to help understand the situation and whether this pathway may be appropriate for your loved one. The person considering the pathway completes it themselves.

  • Preliminary assessmentYour loved one completes a confidential assessment. It looks at their mental and physical health, approaches they have tried, and what they hope this process might support.
  • Professional reviewQualified clinicians review their summary to consider suitability and risk. A screening conversation may be offered where it is relevant.
  • Preparation & in-person daysIf the pathway is appropriate, your loved one continues with preparation, their in-person session in Amsterdam, and integration support afterwards.
  • Integration & follow-upThey are not alone after the experience. We support them in making sense of it and relating it to everyday life.
Learn how the pathway works

What research suggests

In controlled academic studies, some participants with persistent depressive symptoms reported meaningful improvement after psilocybin-assisted sessions, including people who had not found enough relief with other approaches.

Results vary between individuals and study populations. It is not possible to predict how any one person will respond.

See evidence and sources
50–70%of participants in some clinical studies of treatment-resistant depression responded to psilocybin-assisted therapy.Figure pending source verification
30–40%of participants reached remission (sustained improvement) in several clinical studies.Figure pending source verification

Research is evolving. ONCE does not promise specific outcomes.

Curious if this pathway could be relevant for your loved one?

Start a confidential preliminary assessment

Takes about 4 minutes. You read your full summary before any contact details are requested.